Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Micelles01:30

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Two new <i>β</i>-dihydroagarofuran sesquiterpene polyesters from the seeds of <i>Celastrus angulatus</i> Maxim and their nitric oxide inhibitory activity.

Natural product research·2025
Same author

A Benzimidazole-Based Fluorescent Probe for the Selective Recognition of Cobalt (II) Ions.

Molecules (Basel, Switzerland)·2025
Same author

Three novel sesquiterpene polyol esters from the root bark of <i>Celastrus angulatus</i> Maxim and their nitric oxide inhibitory activity.

Natural product research·2024
Same author

Epac activation ameliorates tubulointerstitial inflammation in diabetic nephropathy.

Acta pharmacologica Sinica·2021
Same author

Dialectical behavior therapy-based psychological intervention for woman in late pregnancy and early postpartum suffering from COVID-19: a case report.

Journal of Zhejiang University. Science. B·2020
Same author

Analysis of an improved workflow of endoscope reprocessing for bedside endoscopic diagnosis and treatment on COVID-19 patients<sup></sup>.

Journal of Zhejiang University. Science. B·2020

Related Experiment Video

Updated: Jun 3, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Hyperbranched polycarbonate-based multimolecular micelle with enhanced stability and loading efficiency.

Wei Su1, Xiao-Hua Luo, Hua-Fen Wang

  • 1Key Laboratory of Biomedical Polymers (The Ministry of Education), Department of Chemistry, Wuhan University, Wuhan 430072, China.

Macromolecular Rapid Communications
|March 25, 2011
PubMed
Summary

This study introduces a new catalyst-free method for creating hyperbranched polymers. These polymers form stable, biocompatible micelles ideal for sustained drug delivery of anticancer agents.

More Related Videos

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by &#960;-&#960; Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Related Experiment Videos

Last Updated: Jun 3, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by &#960;-&#960; Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Hyperbranched polymers offer unique properties for advanced applications.
  • Developing efficient and green synthesis methods is crucial for polymer development.
  • Self-assembly of polymers into nanostructures is key for drug delivery systems.

Purpose of the Study:

  • To develop a facile, catalyst-free method for synthesizing hyperbranched hydroxyl-enriched aliphatic polycarbonate.
  • To design and characterize PEG-attached multiarm hyperbranched copolymers (HEHDO-star-mPEG).
  • To evaluate the self-assembly, stability, biocompatibility, and drug delivery capabilities of the synthesized copolymer micelles.

Main Methods:

  • Catalyst-free synthesis of hyperbranched polycarbonate via SCROP strategy.
  • Design and synthesis of HEHDO-star-mPEG copolymers.
  • Investigation of self-assembly into micelles in aqueous solution.
  • Assessment of micellar stability, size, and cell-biocompatibility.
  • Incorporation of doxorubicin for drug delivery studies.

Main Results:

  • Successful synthesis of hyperbranched hydroxyl-enriched aliphatic polycarbonate without catalysts.
  • HEHDO-star-mPEG copolymers self-assemble into stable supramolecular multimolecular micelles in water.
  • Micelles demonstrated excellent stability in size upon dilution and good cell-biocompatibility.
  • The drug delivery system achieved high doxorubicin loading and sustained release.

Conclusions:

  • A facile and green method for preparing hyperbranched polymers was established.
  • HEHDO-star-mPEG micelles are promising nanocarriers for drug delivery due to their stability and biocompatibility.
  • The developed system shows potential for effective anticancer drug delivery with sustained release characteristics.