[Antihypoxic effect of analogs of cyclic adenosine monophosphate, phosphodiesterase inhibitors]

A number of investigated cAMP derivatives are shown to inhibit the cAMP-phosphodiesterase in brain tissues of white rats in vitro. The 8-substituted aminoethylamino-derivatives proved to be effective inhibitors of the enzyme. Among them the most pronounced inhibition displayed the 8-(beta-aminoethylamino)-cAMP. In an in vitro experiment on the model of hypoxic hypoxia in rats it was shown to possess strong anti-hypoxic properties. The possible prospective clinical use of the cAMP analogs--inhibitors of the cAMP-phosphodiesterase--is discussed.