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Serum esterase activities and hyperlipidaemia in the streptozotocin-diabetic rat
B N Patel1, M I Mackness, D W Harty
1Department of Biochemistry and Molecular Biology, University of Manchester Medical School, U.K.
Biochimica Et Biophysica Acta
|July 20, 1990
Abstract:
The levels of activity of four serum esterases were measured in control and streptozotocin-diabetic rats for a period of 6 months. Pseudocholinesterase activity was significantly elevated in the diabetic rats at all time points tested, reaching 250% of the control activity at 6 months. Levels of paraoxonase activity progressively decreased with time in the diabetic rats, being 36% lower than in controls at 6 months. No significant differences in either serum arylesterase or carboxylesterase activity between control and diabetic rats were observed.