Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Minimally invasive extraperitoneal posterior neurectomy for anterior cutaneous nerve entrapment syndrome (ACNES): Primary description of the MEPONE technique and clinical outcomes.

Hernia : the journal of hernias and abdominal wall surgery·2026
Same author

Epitope-Resolved Digital SERS Profiling of Structurally Dynamic Antigens via a Multi-Epitope Bispecific Antibody Framework.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Spatially Profiling Trace Cytokine Signatures From Microscopically Derived Skin Samples to Probe Skin Disease Inflammation.

Small methods·2026
Same author

Multifactor authentication in extracellular vesicle analysis: methods and approaches to address the heterogeneity problem.

Nature methods·2026
Same author

Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes.

Nature communications·2026
Same author

Nanobiosensors and Artificial Intelligence Strategies for Glycan Profiling in Cancer Progression: A Critical Review.

ACS sensors·2026

Related Experiment Video

Updated: Jun 3, 2026

Quantification and Size-profiling of Extracellular Vesicles Using Tunable Resistive Pulse Sensing
12:01

Quantification and Size-profiling of Extracellular Vesicles Using Tunable Resistive Pulse Sensing

Published on: October 19, 2014

Quantitative sizing of nano/microparticles with a tunable elastomeric pore sensor.

Robert Vogel1, Geoff Willmott, Darby Kozak

  • 1School of Mathematics and Physics, The University of Queensland, St. Lucia QLD, Australia. vogel@physics.uq.edu.au

Analytical Chemistry
|March 26, 2011
PubMed
Summary

This study introduces a size-tunable resistive pulse sensor for accurate nano- and microparticle sizing. The method shows good agreement with established techniques for various synthetic and biological particles.

More Related Videos

Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example
08:42

Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example

Published on: October 26, 2016

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

Related Experiment Videos

Last Updated: Jun 3, 2026

Quantification and Size-profiling of Extracellular Vesicles Using Tunable Resistive Pulse Sensing
12:01

Quantification and Size-profiling of Extracellular Vesicles Using Tunable Resistive Pulse Sensing

Published on: October 19, 2014

Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example
08:42

Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example

Published on: October 26, 2016

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

Area of Science:

  • Nanotechnology
  • Materials Science
  • Biophysics

Background:

  • Accurate sizing of nanoparticles and microparticles is crucial for various scientific disciplines.
  • Existing sizing methods can be complex or limited in scope.

Purpose of the Study:

  • To present a novel size-tunable polyurethane resistive pulse sensor for quantitative particle sizing.
  • To demonstrate the sensor's capability in accurately measuring the size of diverse nano- and microparticles.

Main Methods:

  • Utilized a size-tunable polyurethane membrane for resistive pulse sensing.
  • Established a linear calibration curve using monodisperse carboxylated polystyrene particles.
  • Applied the calibration to quantify the size of unknown synthetic (PMMA, polystyrene) and biological (adenovirus) nanoparticles.

Main Results:

  • Observed a linear relationship between particle volume and electrical resistance change, consistent with Maxwell's theory.
  • Successfully quantified particle diameters for a range of synthetic and biological samples.
  • Achieved good agreement between sensor-derived sizes and coefficients of variation with transmission electron microscopy and dynamic light scattering.

Conclusions:

  • The size-tunable resistive pulse sensor offers a reliable method for quantitative sizing of nano- and microparticles.
  • This technique is versatile, applicable to both synthetic and biological nanoparticles.
  • The sensor provides accurate results comparable to established characterization techniques.