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The cyclins: a family of widely expressed tumor antigens?

Michael S von Bergwelt-Baildon1, Eisei Kondo, Nela Klein-González

  • 1Laboratory for Tumor and Transplantation Immunology, Department I of Internal Medicine, University Hospital of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany.

Expert Review of Vaccines
|March 26, 2011
PubMed

Insights

Cyclins are overexpressed in cancer, making them promising targets for immunotherapy. This review highlights cyclins A, B, and D as key targets for cancer treatment and prevention strategies.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Continuous cell division is a hallmark of cancer.
  • Cell-cycle regulators are relevant targets for tumor therapy.
  • Cyclins are overexpressed in various tumors but minimally in normal tissues.

Purpose of the Study:

  • To review evidence of immune system recognition of cyclins.
  • To summarize the potential of cyclins A, B, and D for immunotherapy.
  • To discuss the potential of the cyclin family as novel tumor antigens.

Main Methods:

  • Literature review of scientific evidence.
  • Analysis of cyclin expression patterns in normal and tumor tissues.
  • Evaluation of immune system recognition of cyclins.

Main Results:

  • Cyclins are recognized by the immune system.
  • Cyclins A, B, and D show particular promise for active and passive immunotherapy.
  • The entire cyclin family may represent a novel class of tumor antigens.

Conclusions:

  • Cyclins are viable targets for cancer immunotherapy.
  • Targeting cyclins offers potential for cancer treatment and prevention.
  • Further research into the cyclin family as tumor antigens is warranted.

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