Related Experiment Video

Updated: Jun 3, 2026

Transmitochondrial Cybrid Generation Using Cancer Cell Lines
07:49

Transmitochondrial Cybrid Generation Using Cancer Cell Lines

Published on: March 17, 2023

Harnessing impaired energy metabolism in cancer cell: small molecule- mediated ways to regulate tumorigenesis

K Shroff Govardhan1, Kuna Ramyasri1, Dirisipam Kethora1

  • 1Chemical Biology Programme, Institute of Life Sciences, Hyderabad, University of Hyderabad Campus, Gachibowli, Hyderabad, 500032, India

Anti-Cancer Agents in Medicinal Chemistry
|March 26, 2011
PubMed

Insights

Cancer cells reprogram metabolism for survival and proliferation. This review explores signaling molecules and small molecule interventions targeting cancer cell metabolic changes to inhibit tumor growth.

Area of Science:

  • Oncology
  • Cellular Metabolism
  • Cancer Signaling

Background:

  • Altered cellular metabolism is a key characteristic of cancer development.
  • Cancer cells exhibit metabolic reprogramming for nutrient self-sufficiency, supporting proliferation and survival.
  • This metabolic shift is driven by complex interactions between diverse signaling cascades.

Purpose of the Study:

  • To review signaling molecules that regulate metabolic alterations in cancer cells.
  • To emphasize small molecule-mediated interventions for cancer therapy.
  • To discuss the attenuation of tumor growth and progression through metabolic targeting.

Main Methods:

  • Literature review of signaling pathways involved in cancer metabolism.
  • Analysis of small molecule inhibitors targeting metabolic reprogramming.
  • Synthesis of current understanding on metabolic interventions in oncology.

Main Results:

  • Identification of key signaling molecules driving cancer-specific metabolic changes.
  • Overview of the therapeutic potential of small molecules targeting these pathways.
  • Demonstration of how metabolic reprogramming contributes to tumor progression.

Conclusions:

  • Targeting signaling pathways that regulate cancer cell metabolism offers a promising therapeutic strategy.
  • Small molecule interventions hold potential for attenuating tumor growth and progression.
  • Understanding the interplay between signaling and metabolism is crucial for developing effective cancer treatments.

More Related Videos

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures07:48

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Published on: December 26, 2016

Related Concept Videos

Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...