Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structurally constrained and pathology-aware convolutional transformer generative adversarial network for virtual histology staining of human coronary optical coherence tomography images.

Journal of biomedical optics·2024
Same author

Clinical characteristics and outcomes of patients requiring prolonged mechanical circulatory support after high-risk percutaneous coronary intervention.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·2024
Same author

Atherosclerotic three-layer nanomatrix vascular sheets for high-throughput therapeutic evaluation.

Biomaterials·2024
Same author

Multilevel Assessment of Stent-Induced Inflammation in the Adjacent Vascular Tissue.

ACS biomaterials science & engineering·2023
Same author

Randomized trial of an oblique versus standard fluoroscopic-guided micropuncture technique for femoral arterial access: The Micropuncture-CFA trial.

Cardiovascular revascularization medicine : including molecular interventions·2023
Same author

The Calcified Nodule Paradox.

JACC. Cardiovascular interventions·2023

Related Experiment Video

Updated: Jun 3, 2026

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
09:09

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

Microarray applications in occlusive vascular disease.

Jing Chen1, Traci T Goodchild, Brigitta C Brott

  • 1Department of Cardiology, Renmin Hospital of Wuhan University, China.

Cardiovascular & Hematological Agents in Medicinal Chemistry
|March 26, 2011
PubMed
Summary
This summary is machine-generated.

Microarray analysis reveals gene expression profiles for vascular diseases like atherosclerosis. This review explores methods and targets to improve diagnosis and treatment of occlusive vascular conditions.

More Related Videos

Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease
08:38

Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease

Published on: August 26, 2017

Related Experiment Videos

Last Updated: Jun 3, 2026

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
09:09

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease
08:38

Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease

Published on: August 26, 2017

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Genomics

Background:

  • Occlusive vascular diseases are treated with interventions and drugs, but molecular mechanisms remain poorly understood.
  • Microarray technology enables simultaneous analysis of thousands of genes, offering insights into disease processes.
  • Previous microarray studies have yielded valuable expression data for atherosclerosis and in-stent stenosis.

Purpose of the Study:

  • To review the latest microarray research identifying gene-expression profiles in vascular diseases.
  • To analyze the methodologies of existing microarray studies.
  • To identify biological pathways and potential diagnostic/therapeutic targets for atherosclerosis and in-stent stenosis.

Main Methods:

  • Comprehensive literature review of microarray studies focused on atherosclerosis and in-stent stenosis.
  • Analysis of gene-expression data to identify significant profiles.
  • Pathway analysis to understand underlying biological processes.
  • Evaluation of identified targets for diagnostic and therapeutic potential.

Main Results:

  • Summary of key gene-expression profiles identified through recent microarray research.
  • Assessment of the strengths and limitations of current microarray study designs and interpretations.
  • Identification of specific biological pathways implicated in occlusive vascular diseases.
  • Highlighting of potential novel diagnostic markers and therapeutic targets.

Conclusions:

  • Improved microarray interpretation and study design are crucial for advancing our understanding of vascular diseases.
  • Further research integrating clinical evaluation will enhance the translation of microarray findings into improved patient treatments.
  • Microarray technology holds significant promise for uncovering molecular targets to combat atherosclerosis and in-stent stenosis.