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Updated: Jun 3, 2026
11:17
Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
The discovery and development of rivaroxaban
Frank Misselwitz1, Scott D Berkowitz, Elisabeth Perzborn
1Therapeutic Area Cardiovascular and Coagulation, Global Clinical Development, Bayer HealthCare AG, Wuppertal, Germany.
Annals of the New York Academy of Sciences
|March 26, 2011
Summary
Rivaroxaban is a new oral anticoagulant for preventing blood clots after hip or knee surgery. It is the first direct Factor Xa inhibitor approved for this use, offering a more convenient option.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
- Hematology
Background:
- Thromboembolic conditions cause significant morbidity and mortality.
- Current anticoagulants have management challenges.
- New oral anticoagulants are needed for improved convenience and efficacy.
Purpose of the Study:
- To describe the development of rivaroxaban.
- To discuss the future potential of rivaroxaban.
- To highlight rivaroxaban as the first oral, direct Factor Xa inhibitor for clinical use.
Main Methods:
- Review of the development of rivaroxaban.
- Analysis of clinical approval for specific indications.
Main Results:
- Rivaroxaban is the first approved oral, direct Factor Xa inhibitor.
- Approved for prevention of venous thromboembolism in patients undergoing hip or knee replacement surgery.
Conclusions:
- Rivaroxaban represents a significant advancement in anticoagulant therapy.
- Offers a more convenient and effective option for thromboembolism prevention.
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