Related Experiment Video

Updated: Jun 3, 2026

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
09:40

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications

Jiri Sana1, Marian Hajduch, Jaroslav Michalek

  • 1Masaryk Memorial Cancer Institute, Department of Comprehensive Cancer Care, Brno, Czech Republic.

Journal of Cellular and Molecular Medicine
|March 26, 2011
PubMed

Insights

MicroRNAs (miRNAs) are key regulators implicated in glioblastoma development and progression. This review highlights their role in signaling pathways, drug resistance, and potential as therapeutic targets.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
  • Dysregulated miRNA expression is linked to various cancers, including glioblastoma.
  • miRNAs influence critical cellular processes like proliferation, apoptosis, and angiogenesis.

Purpose of the Study:

  • To review the significance of miRNAs in glioblastoma.
  • To focus on miRNA involvement in core signaling pathways.
  • To discuss their role in drug resistance and clinical implications.

Main Methods:

  • Literature review of scientific articles on miRNAs and glioblastoma.
  • Analysis of miRNA involvement in glioblastoma signaling pathways.
  • Examination of miRNA roles in therapeutic resistance.

Main Results:

  • miRNAs are significantly dysregulated in glioblastoma.
  • These molecules modulate key pathways controlling cell behavior.
  • miRNAs are implicated in glioblastoma drug resistance.

Conclusions:

  • miRNAs are crucial in glioblastoma pathogenesis.
  • Targeting miRNAs offers potential therapeutic strategies for glioblastoma.
  • Further research into clinical applications of miRNAs is warranted.

More Related Videos

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections05:45

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...