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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...

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Related Experiment Video

Updated: Jun 3, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Acute stroke intervention.

Alexander A Khalessi1, Sabareesh K Natarajan, David Orion

  • 1Department of Neurosurgery and Toshiba Stroke Research Center, University at Buffalo, State University of New York, USA.

JACC. Cardiovascular Interventions
|March 26, 2011
PubMed
Summary

This review covers endovascular treatments for acute ischemic stroke, detailing the evolution from systemic thrombolysis to advanced mechanical thrombectomy and stenting techniques for improved patient outcomes.

Related Experiment Videos

Last Updated: Jun 3, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Area of Science:

  • Neurology
  • Interventional Cardiology
  • Vascular Surgery

Background:

  • Acute ischemic stroke requires timely intervention to restore blood flow.
  • Intravenous thrombolysis has limitations in severe cases.
  • Endovascular techniques offer direct revascularization.

Purpose of the Study:

  • To review the current state-of-the-art in endovascular stroke management.
  • To trace the evolution of treatment modalities.
  • To identify future research directions.

Main Methods:

  • Systematic review of endovascular techniques for acute ischemic stroke.
  • Discussion of intravenous thrombolysis, intra-arterial thrombolysis, and mechanical thrombectomy devices (Merci, Penumbra).
  • Review of angioplasty, intracranial stenting, and stentriever devices.

Main Results:

  • Endovascular management has shifted from a competing to a complementary role alongside systemic thrombolysis.
  • Mechanical thrombectomy and advanced devices have become integral to stroke treatment.
  • A range of endovascular options are available for acute ischemic stroke.

Conclusions:

  • Endovascular therapy is a cornerstone of modern acute ischemic stroke management.
  • Continuous innovation in devices and techniques is crucial for improving outcomes.
  • Further research is needed to optimize patient selection and treatment protocols.