Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypothesis: lipoprotein(a) is a surrogate for ascorbate.

M Rath1, L Pauling

  • 1Linus Pauling Institute of Science and Medicine, Palo Alto, CA 94306.

Proceedings of the National Academy of Sciences of the United States of America
|August 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A nutrient mixture reduced tumor growth of SK-UT-1 human leiomyosarcoma cells in vivo and in vitro by inhibiting MMPs and inducing apoptosis.

Experimental oncology·2021
Same author

FvSTUA is a Key Regulator of Sporulation, Toxin Synthesis, and Virulence in <i>Fusarium verticillioides</i>.

Molecular plant-microbe interactions : MPMI·2020
Same author

The changing landscape of infective endocarditis in South Africa.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2019
Same author

Down regulation of u-PA by a nutrient mixture in hemangioma (EOMA) cells by inducing caspase-dependent apoptosis.

Experimental oncology·2018
Same author

Volatiles produced by Bacillus mojavensis RRC101 act as plant growth modulators and are strongly culture-dependent.

Microbiological research·2018
Same author

Photoinactivation of <i>Legionella Rubrilucens</i> by Visible Light.

European journal of microbiology & immunology·2017

Lipoprotein(a) [Lp(a)] may function as a substitute for ascorbate (Vitamin C) in species unable to produce it. This hypothesis is supported by shared properties and associations with diseases like cardiovascular disease.

Area of Science:

  • Biochemistry
  • Evolutionary Biology
  • Human Physiology

Background:

  • Certain species, like primates and guinea pigs, cannot synthesize ascorbate (Vitamin C).
  • Lipoprotein(a) [Lp(a)] is present in these species but rare in others.
  • Lp(a) shares functional similarities with ascorbate.

Purpose of the Study:

  • To propose and evaluate the hypothesis that Lp(a) acts as an ascorbate surrogate.
  • To review evidence supporting the Lp(a)-ascorbate surrogate concept.

Main Methods:

  • Comparative analysis of Lp(a) and ascorbate properties.
  • Review of existing literature on Lp(a), ascorbate, and related diseases.
  • Examination of species-specific ascorbate synthesis and Lp(a) presence.

Related Experiment Videos

Main Results:

  • Lp(a) and ascorbate share functions: wound healing, extracellular matrix strengthening, and preventing lipid peroxidation.
  • High plasma Lp(a) correlates with coronary heart disease, similar to ascorbate's protective effects.
  • Similar associations observed in cancer and diabetes.

Conclusions:

  • Lp(a) is hypothesized to be a functional surrogate for ascorbate in species lacking endogenous synthesis.
  • The shared properties and disease associations provide evidence for this evolutionary adaptation hypothesis.