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Related Experiment Video

Updated: Jun 3, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

The circadian clock in the kidney.

Lisa R Stow¹, Michelle L Gumz

¹Biochemistry and Molecular Biology and †Medicine, Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville, Florida 32610, USA.

Journal of the American Society of Nephrology : JASN

|March 26, 2011

Summary

The kidney exhibits daily rhythms in function, regulated by the body's internal clock. Understanding these circadian rhythms is crucial for managing kidney disease and hypertension.

Area of Science:

Nephrology
Chronobiology
Molecular Biology

Background:

Circadian variations in renal function, including glomerular filtration rate (GFR), renal blood flow, and electrolyte excretion, have been observed for centuries.
Despite established clinical observations, the precise molecular mechanisms governing these daily kidney function fluctuations remain largely unknown.

Purpose of the Study:

To provide an overview of the molecular machinery controlling circadian rhythms.
To examine clinical and molecular evidence highlighting the critical role of circadian rhythms in kidney function.
To explore the connection between blood pressure (BP) oscillations, renal disease, and chronotherapy.

Main Methods:

Review of existing literature on circadian clock machinery.

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Last Updated: Jun 3, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

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Published on: November 11, 2016

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

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Published on: September 28, 2017

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Published on: September 17, 2016

Analysis of clinical data linking BP variations to renal disease and treatment outcomes.

Examination of molecular studies, including rodent and cellular models, to identify clock-controlled genes in the kidney.

Main Results:

Established clinical observations of daily renal function oscillations.
Evidence supporting the role of circadian rhythms in regulating sodium and water transport in renal epithelial cells.
Identification of novel clock-controlled genes offering insights into molecular mechanisms.

Conclusions:

Circadian rhythms play a critical role in kidney function.
Understanding these rhythms is essential for developing chronotherapeutic strategies for hypertension and renal disease.
Further research is needed to fully elucidate the molecular mechanisms involved.