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Genetic polymorphism of complement factor H in cattle
H Tabel1, H J Groat, G J Kraay
1Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Canada.
Abstract:
Bovine factor H was found to be polymorphic by the combined techniques of SDS-polyacrylamide electrophoresis of bovine plasma and immunoblotting. Three phenotypes (S, SF, F) were identified in a sample population of 149 cattle. Variant S and F differed by an apparent molecular weight of 5000 daltons. Family studies demonstrated Mendelian segregation of variants S and F. The data indicate that these genetic variants of bovine factor H are encoded by two codominant alleles at a single autosomal locus.
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