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Genetic polymorphism of complement factor H in cattle.

H Tabel1, H J Groat, G J Kraay

  • 1Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Canada.

Animal Genetics
|January 1, 1990
PubMed
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Genetic variations in bovine factor H were identified using electrophoresis and immunoblotting. These findings suggest two codominant alleles control bovine factor H, impacting cattle genetics.

Area of Science:

  • Immunogenetics
  • Proteomics
  • Animal Genetics

Background:

  • Factor H is a crucial complement regulatory protein.
  • Understanding genetic variations in bovine Factor H is important for animal health and breeding.
  • Previous studies have not fully characterized the genetic polymorphism of bovine Factor H.

Purpose of the Study:

  • To investigate the genetic polymorphism of bovine Factor H.
  • To identify different phenotypes of bovine Factor H in cattle.
  • To determine the inheritance pattern of bovine Factor H variants.

Main Methods:

  • Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of bovine plasma.
  • Immunoblotting techniques to detect Factor H variants.
  • Family studies to analyze segregation patterns.

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Main Results:

  • Bovine Factor H exhibits polymorphism, with three identified phenotypes: S, SF, and F.
  • Variant S and F differ by approximately 5000 daltons in molecular weight.
  • Mendelian segregation of S and F variants was observed in family studies.

Conclusions:

  • The genetic variants of bovine Factor H are controlled by two codominant alleles.
  • These alleles are located at a single autosomal locus.
  • This polymorphism has implications for bovine immunogenetics and breeding programs.