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Effect of methyl isocyanate (MIC) on rat erythrocytes
D Agrawal1, G S Gupta, J S Shukla
1Industrial Toxicology Research Centre, Lucknow, India.
Archives of Toxicology
|January 1, 1990
Abstract:
Changes in surface morphology of rat erythrocytes were studied by scanning electron microscopy after a single and repeated exposure of methyl isocyanate under static conditions. Marked morphological changes (echinocytes and spherocytes) were observed, followed by an increase in osmotic fragility of the erythrocyte membrane. The activity of the membrane bound enzyme adenosine triphosphatase (Na+, K+, Mg++) was inhibited.