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Related Experiment Video

Updated: Jun 3, 2026

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
06:51

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

Risk factors for necrotizing enterocolitis totalis: a case-control study.

A Thompson1, M Bizzarro, S Yu

  • 1Division of Neonatology, Department of Pediatrics, Children's Hospital at Montefiore, Bronx, NY 10461, USA. alethomp@montefiore.org

Journal of Perinatology : Official Journal of the California Perinatal Association
|March 26, 2011
PubMed
Summary
This summary is machine-generated.

Breast milk feeding significantly reduces the risk of necrotizing enterocolitis totalis (NEC-T) in preterm infants. Further biological data is needed to fully understand NEC-T risk factors.

More Related Videos

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
08:42

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

Published on: April 10, 2019

Related Experiment Videos

Last Updated: Jun 3, 2026

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
06:51

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
08:42

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

Published on: April 10, 2019

Area of Science:

  • Neonatal Medicine
  • Gastroenterology
  • Pediatric Surgery

Background:

  • Necrotizing enterocolitis (NEC) is a severe gastrointestinal emergency in preterm infants.
  • Distinguishing between total NEC (NEC-T) and non-total NEC (NEC non-T) is crucial for understanding disease progression and outcomes.

Purpose of the Study:

  • To compare demographic and clinical characteristics of preterm neonates with NEC-T, NEC non-T, and those without NEC.
  • To identify factors associated with the development of NEC-T.

Main Methods:

  • Retrospective case-control study at Yale New Haven Children's Hospital (1991-2007).
  • Included preterm infants (<36 weeks GA) without GI malformations.
  • Matched cases (NEC-T) with controls (NEC non-T and non-NEC) by gestational age.

Main Results:

  • Breast milk feeding was associated with a significantly decreased risk of NEC-T in both NEC-T vs. NEC non-T and NEC-T vs. non-NEC comparisons.
  • Full enteral feeds prior to diagnosis were associated with increased NEC-T risk when compared to non-NEC controls.

Conclusions:

  • Breast milk consumption is a protective factor against NEC-T in preterm neonates.
  • Most demographic and clinical variables did not significantly differ between groups, emphasizing the need for more biological insights into NEC-T development.