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Updated: Jun 3, 2026

Effects of Mechanical Methods Used in Peri-implantitis Treatment on Implant Surface Decontamination and Roughness
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Effects of Mechanical Methods Used in Peri-implantitis Treatment on Implant Surface Decontamination and Roughness

Published on: March 14, 2025

Validated surrogate endpoints needed for peri-implantitis.

Dong Won Lee1

  • 1Department of Periodontology, Gangnam Severance Hospital, College of Dentistry, Yonsei University, Seoul, Korea.

Evidence-Based Dentistry
|March 26, 2011
PubMed
Summary
This summary is machine-generated.

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Current peri-implantitis treatment studies lack true patient benefit endpoints. Research primarily uses surrogate markers like pocket depth, necessitating validation for accurate clinical assessment of peri-implantitis therapy effectiveness.

Area of Science:

  • Dental Implantology
  • Periodontology
  • Evidence-Based Dentistry

Background:

  • Systematic review of randomized controlled trials and non-randomized studies on peri-implantitis treatment.
  • Searched multiple databases (PubMed, Cochrane, Lilac) and hand-searched major dental journals and systematic review reference lists.
  • Included human studies in multiple languages, excluding case reports and non-therapy studies.

Discussion:

  • Analysis of 14 studies revealed no use of true endpoints (e.g., implant failure, quality of life) directly measuring patient benefit.
  • Commonly reported outcomes were surrogate endpoints such as probing pocket depth, clinical attachment level, and bleeding on probing.
  • Discrepancies in data extraction and consensus resolution were managed by duplicate review.

Key Insights:

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Published on: May 9, 2022

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Last Updated: Jun 3, 2026

Effects of Mechanical Methods Used in Peri-implantitis Treatment on Implant Surface Decontamination and Roughness
06:36

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Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
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  • Peri-implantitis treatment research predominantly relies on surrogate endpoints, not direct measures of patient well-being or implant survival.
  • Implant failure was only reported as a consequence of therapy, not as a primary research objective.
  • The validity of surrogate endpoints in reflecting true clinical benefit remains unconfirmed.

Outlook:

  • Future research must prioritize the validation of surrogate endpoints against true clinical endpoints in peri-implantitis treatment.
  • Development of standardized outcome measures is crucial for reliable assessment of therapeutic efficacy.
  • A shift towards patient-centered outcomes is needed to guide clinical decision-making in managing peri-implantitis.