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Related Concept Videos

The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
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Membrane Transporters

Transporters are essential membrane transport proteins with functions related to cell nutrition, homeostasis, communication, etc. Approximately 7% of all genes in the human genome code for transporters or transporter-related proteins.
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Carrier-Mediated Transport

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Active Transport01:14

Active Transport

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Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
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The Significance of Membrane Transport

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Related Experiment Video

Updated: Jun 3, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Human iron transporters.

Michael D Garrick1

  • 1Department of Biochemistry, 140 Farber Hall, SUNY at Buffalo, 3435 Main St., Buffalo, NY 14214 USA.

Genes & Nutrition
|March 26, 2011
PubMed
Summary
This summary is machine-generated.

Human iron transporters, like DMT1, are crucial for cellular function. This review explores why DMT1 levels exceed needs and discusses new research on iron transport mechanisms.

Keywords:
Divalent metal transporter (DMT1)Ferric reductaseFerroportinIron regulatory protein (IRP)Iron-responsive element (IRE)IsoformsTransferrin

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Last Updated: Jun 3, 2026

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Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

Area of Science:

  • Biochemistry
  • Cell Biology
  • Physiology

Background:

  • Iron is essential for critical cellular functions, but its excess can lead to harmful reactive oxygen species.
  • Iron uptake in the duodenum primarily involves divalent metal transporter 1 (DMT1) and ferroportin.
  • The transferrin cycle is a major pathway for iron trafficking within the body.

Purpose of the Study:

  • To investigate the reasons behind the seemingly redundant levels of DMT1 in human iron management.
  • To review advancements in understanding iron transport mechanisms beyond 2008.
  • To explore the roles of various iron transporters in non-digestive tissues.

Main Methods:

  • Literature review of scientific publications and research findings.
  • Analysis of existing data on iron transporter expression and function.
  • Synthesis of recent advances in the field of iron metabolism.

Main Results:

  • DMT1 levels often exceed the requirements for known iron uptake and trafficking pathways.
  • Non-digestive tissues possess diverse iron transporters that may compensate for DMT1.
  • Recent research has shed light on alternative iron transport mechanisms and their regulation.

Conclusions:

  • The precise physiological role of elevated DMT1 levels requires further investigation.
  • Multiple iron transporters contribute to cellular iron homeostasis, suggesting functional redundancy.
  • Advances since 2008 highlight the complexity of iron management in human tissues.