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Updated: Jun 3, 2026
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In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
Published on: August 16, 2013
Imaging inflammatory plasma leakage in vivo
1Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. ellinor.kenne@ki.se
Thrombosis and Haemostasis
|March 26, 2011
Summary
Intravital imaging techniques visualize inflammatory plasma leakage. Different optical and non-optical methods offer varying resolutions, invasiveness, and availability for studying vascular permeability.
Area of Science:
- Physiology
- Biomedical Imaging
- Inflammation Research
Background:
- Vascular permeability and plasma leakage are key indicators of inflammation.
- Excessive leakage can cause severe health complications, including pneumonia, burns, and brain injury.
- Intravital imaging has advanced the understanding of inflammatory vascular changes.
Purpose of the Study:
- To review and discuss various intravital imaging techniques for visualizing inflammatory plasma leakage.
- To compare the capabilities and limitations of different imaging modalities.
Main Methods:
- Optical techniques: Intravital fluorescence microscopy, near-infrared fluorescence imaging.
- Non-optical techniques: Magnetic resonance imaging (MRI), radioisotopic imaging.
- Comparison based on spatial/temporal resolution, invasiveness, and availability.
Main Results:
- Intravital imaging allows in vivo visualization of inflammatory plasma leakage.
- Optical methods are common in experimental settings; MRI and radioisotopic imaging are used clinically and experimentally.
- Techniques differ significantly in resolution, invasiveness, and accessibility.
Conclusions:
- A range of intravital imaging techniques are available for studying inflammatory plasma leakage.
- The choice of technique depends on specific research or clinical needs regarding resolution and invasiveness.
- Continued development of these imaging modalities enhances our understanding of inflammatory processes.
