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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Acute Inflammation II: Cellular Phase01:26

Acute Inflammation II: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

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Updated: Jun 3, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
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A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

Neutrophilic dermatoses: part I.

Renan Rangel Bonamigo1, Fernanda Razera, Gislaine Silveira Olm

  • 1Pathology Postgraduate Program and Head of the Dermatology Service, Health Sciences Federal University of Porto Alegre, Brazil. bonamigorenan@ufcspa.edu.br

Anais Brasileiros De Dermatologia
|March 26, 2011
PubMed
Summary

This review covers neutrophilic dermatoses like Sweet syndrome and pyoderma gangrenosum, detailing their clinical features, pathology, and treatment options for better patient health outcomes.

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Last Updated: Jun 3, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

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Imaging Neutrophil Migration in the Mouse Skin to Investigate Subcellular Membrane Remodeling Under Physiological Conditions
08:41

Imaging Neutrophil Migration in the Mouse Skin to Investigate Subcellular Membrane Remodeling Under Physiological Conditions

Published on: May 10, 2022

Area of Science:

  • Dermatology
  • Internal Medicine

Background:

  • Neutrophilic dermatoses significantly impact patient health.
  • Key conditions include Sweet syndrome, pyoderma gangrenosum, Behçet's disease, and neutrophilic urticaria.

Purpose of the Study:

  • To review major neutrophilic dermatoses.
  • To discuss clinical, histopathological, and management aspects.

Main Methods:

  • Literature review of recent studies.
  • Incorporation of authors' clinical experience.

Main Results:

  • Detailed discussion of clinical presentations.
  • Explanation of histopathological findings.
  • Overview of current management strategies.

Conclusions:

  • Provides a comprehensive overview of important neutrophilic dermatoses.
  • Aids clinicians in diagnosis and treatment.
  • Highlights the need for continued research and experience-based management.