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Updated: Jun 3, 2026

Particles without a Box: Brush-first Synthesis of Photodegradable PEG Star Polymers under Ambient Conditions
Published on: October 10, 2013
"Clip" and "click" chemistries combination: toward easy PEGylation of degradable aliphatic polyesters
Hélène Freichels1, Vincent Pourcelle, Cécile S Le Duff
1Center for Education and Research on Macromolecules (CERM), University of Liège, Sart-Tilman B6a, B-4000 Liège, Belgium.
Abstract:
α-Methoxy-ω-alkyne poly(ethylene glycol) (PEG) was tagged with pendent N-hydroxy-succinimidyl activated esters by photografting of a molecular clip. This easily synthesized heterofunctional PEG was found to be a versatile building block for (i) conjugation with an amino derivative and (ii) grafting to azido functional aliphatic polyesters backbone by Huisgen's 1,3-dipolar cycloaddition. This original combination of "clip" and "click" reactions provides a versatile and straightforward pathway for the synthesis of functional amphiphilic and degradable copolymers valuable for biomedical applications such as in drug-delivery.
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