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Antimicrobial Effectiveness

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...

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Updated: Jun 3, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

[Progress in antimicrobial therapy].

Sinisa Sević¹, Sandra Stefan-Mikić, Jovan Vukadinov

¹Klinika za infektivne bolesti, Klinicki centar Vojvodine, Novi Sad, Hajduk Veljkova. sevicsinisa@yahoo.com

Medicinski Pregled

|March 29, 2011

Summary

Natural products revolutionized medicine by combating infectious diseases, but antibiotic discovery has declined significantly since the 1970s, necessitating global action.

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

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Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

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Published on: April 18, 2019

Area of Science:

Pharmacology and Natural Products Chemistry
History of Medicine
Microbiology

Context:

Infectious diseases were leading causes of death globally in the early 1900s.
Bioactive natural products and their derivatives significantly increased human lifespan in the 20th century.
Antibiotics, largely derived from nature, are crucial antimicrobial agents.

Purpose:

To trace the historical progression of antimicrobial drug development.
To highlight the decline in the discovery of new antibiotics since the "golden age" (1940s-1970s).
To underscore the urgent need for global strategies in antimicrobial therapy.

Summary:

The discovery of new antimicrobial drugs peaked between the 1940s and 1970s.
A marked decrease in new antibiotic registrations occurred, with only four approved between 2003-2007.
This decline signals a critical juncture in the fight against infectious diseases.

Impact:

The historical reliance on natural products for drug discovery has yielded significant health benefits.
The diminishing pipeline of new antibiotics poses a global health threat.
A coordinated global response is essential for monitoring antimicrobial resistance and investing in new therapeutic research.