Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antimicrobial Effectiveness

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...

Clinical Significance of Antibiotic Resistance

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

Antibiotic Selection

Antibiotic Selection

Combined Effects of Drugs: Synergism

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...

Antifungal Agents

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Underrecognized Tick-Borne Encephalitis in Serbia: Evidence from Patients with Suspected West Nile Virus Neuroinvasive Disease.

Pathogens (Basel, Switzerland)·2026

Same author

Analysis of West Nile disease convalescents identifies human monoclonal antibodies protective against West Nile and related orthoflaviviruses.

Immunity·2026

Same author

The Prognostic Value of Cardiac Biomarkers in Combination with the SOFA Score for the Evaluation of Sepsis-Related Mortality.

Medicina (Kaunas, Lithuania)·2026

Same author

Human antibodies against West Nile and related orthoflaviviruses.

bioRxiv : the preprint server for biology·2026

Same author

Spatiotemporal and Demographic Patterns of West Nile Neuroinvasive Disease in Vojvodina, Serbia, 2012-2025.

Viruses·2026

Same author

Inflammatory parameters in the prediction of sepsis-induced acute kidney injury: a case-control study.

BMC infectious diseases·2025

Search research articles

Related Experiment Video

Updated: Jun 3, 2026

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

[Novelties in antimicrobial therapy].

Jovan Vukadinov¹, Sinisa Sević, Radoslava Doder

¹Klinika za infektivne bolesti, Klinicki centar Vojvodine, Novi Sad, Hajduk Veljkova. nsinfekt@gmail.com

Medicinski Pregled

|March 29, 2011

Summary

The discovery of new antimicrobial drugs has lagged significantly. Since 2000, only a few new antibacterial and antifungal medications have been approved for human use, with associated risks discussed.

More Related Videos

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

Related Experiment Videos

Last Updated: Jun 3, 2026

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

Area of Science:

Microbiology and Pharmacology
Evolution of life and microbial genetics

Context:

Microorganisms represent the oldest life forms, exhibiting rapid generational turnover and genetic adaptability.
The human microbiome significantly outnumbers human cells, highlighting the importance of microbial balance.
A critical gap in antimicrobial drug development occurred between 1968 and 2000, with no new drugs discovered.

Purpose:

To review newly approved antimicrobial drugs for human medicine since the year 2000.
To detail the characteristics of these novel antimicrobial agents.
To outline the potential risks associated with their clinical application in antimicrobial therapy.

Summary:

Since 2000, two new antibacterial drugs and one new antifungal drug have been approved for human use.
This paper provides a comprehensive overview of these recently approved antimicrobial medications.
The review includes an analysis of their pharmacological properties and safety profiles.

Impact:

Informing healthcare professionals about the latest advancements in antimicrobial pharmacotherapy.
Facilitating informed clinical decision-making regarding the use of new antimicrobial agents.
Contributing to the ongoing efforts to combat antimicrobial resistance through updated therapeutic options.