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Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
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Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
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Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
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[Drug use among workers: an update].

V Crespi1, A Borsani, G Veronesi

  • 1Medicina del Lavoro e Preventiva, Ospedale di Circolo-Fondazione Macchi, Varese, Italy. valeria.crespi@ospedale.varese.it

Giornale Italiano Di Medicina Del Lavoro Ed Ergonomia
|March 29, 2011
PubMed
Summary

Workplace drug testing revealed a 1.6% positivity rate, with cannabis and cocaine being the most prevalent substances. Younger age and co-worker positivity were linked to increased drug use detection.

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Area of Science:

  • Occupational Health
  • Forensic Toxicology
  • Public Health

Context:

  • Recent legislation mandates drug use surveillance in the workplace.
  • Data collected over two years (September 2008 - April 2010) from worker surveillance programs.
  • Includes self-reported job duties and drug use history.

Purpose:

  • To present findings from a two-year workplace drug surveillance program.
  • To identify prevalence and patterns of drug use among workers.
  • To analyze factors associated with positive drug test results.

Summary:

  • A total of 2745 workers were screened, with 3002 urine samples analyzed.
  • A 1.6% positivity rate (46 out of 2878 valid samples) was observed.
  • Cannabis and cocaine were the most frequently detected drugs.
  • No significant temporal trends in drug use were identified.
  • Younger age and the presence of other positive samples within the same company were associated with higher positivity rates.
  • Additional analysis of urine and hair samples from 146 suspected drug abusers is presented.

Impact:

  • Provides crucial data on workplace drug use prevalence and trends.
  • Informs occupational health policies and workplace safety initiatives.
  • Highlights the need for targeted prevention and intervention strategies in specific demographics or work environments.