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Related Experiment Video

Updated: Jun 3, 2026

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery

Published on: September 26, 2025

[Formulation study on cryptotanshinone gel for topical administration].

Zhenwei Yu¹, Wenquan Liang

¹Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica

|March 29, 2011

Summary

This summary is machine-generated.

This study optimized cryptotanshinone gel formulations for topical acne treatment. The best formulation utilized 5% azone, showing superior drug retention and transdermal flux for enhanced efficacy.

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Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery

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Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging

Published on: November 24, 2021

Area of Science:

Pharmacology
Dermatology
Materials Science

Background:

Topical diseases like acne require effective drug delivery systems.
Cryptotanshinone is a promising compound for treating inflammatory skin conditions.
Developing optimized gel formulations is crucial for enhancing therapeutic outcomes.

Purpose of the Study:

To screen and identify optimal cryptotanshinone gel formulations for topical disease treatment, specifically acne.
To evaluate the impact of various penetration enhancers on cryptotanshinone delivery.
To determine the ideal enhancer concentration for maximizing therapeutic potential.

Main Methods:

Carbopol 934L was used as the matrix for preparing cryptotanshinone gels.
Gels incorporated different penetration enhancers (menthol, azone) at varying concentrations.
Transdermal drug flux and skin drug retention were assessed using in vitro diffusion cells with excised rat skin.

Main Results:

Menthol and azone enhanced transdermal flux and skin retention, with 5% azone showing the highest efficacy.
The optimal ratio of drug retention amount to transdermal drug flux was achieved with 5% azone.
Combinations of enhancers did not yield superior results compared to single enhancer applications.

Conclusions:

The optimal cryptotanshinone gel formulation for topical application contains 5% azone.
This formulation demonstrates enhanced drug retention and transdermal flux, suggesting improved efficacy for treating topical diseases like acne.