Related Experiment Video
Updated: Jun 3, 2026

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
Published on: November 24, 2021
[Study on transdermal absorption of piperine in Erxiekang plaster]
Yeli Gao1, Jian Ni, Xingbin Yin
1Beijing University of Chinese Medicine, Beijing 100102, China.
Objective:
To research the absorbed character of piperine in Erxiekang plaster, and piperine by transdermal absorption was determined.
Method:
The percutaneous absorption of piperine in vitro at different times was conducted by Franz osmosis and diffusion apparatus as well as high-performance liquid chromatography.
Result:
It showed that the piperine through skins of mice gradually increased within the experiment time. After 52 h, the penetration of piperine was 78.51%, and remained basically unchanged.
Conclusion:
The method is reliable, and can be used for Erxiekang plaster of determination of transdermal absorption.
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