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Updated: Jun 3, 2026

Synthesis of a Water-soluble Metal–Organic Complex Array
Published on: October 8, 2016
Synthesis of arrays using low molecular weight MPEG-assisted Mitsunobu reaction
Marek Figlus1, Natalie Wellaway, Anthony W J Cooper
1WestCHEM Department of Chemistry, University of Glasgow, Glasgow, G12 8QQ, United Kingdom.
Abstract:
Triphenylphosphine tagged with a short poly-(ethyleneglycol)-ω-monomethyl ether chain (light MPEG, 10−16 ethylenoxy units, (M)TPP-G2) and an MPEG-tagged version of diethyl azodicarboxylate ((M)DEAD) have been used to prepare a 20 member library of esters, ethers, and sulfonamides, with cLogP's in the range of 1.4−5.7 on a 0.1 mmol scale. Removal of MPEG-tagged side products was achieved by MPEG-assisted solid-phase extraction (MSPE) on prepacked silica columns to give the products in good yield and high purity.
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