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Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
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CNS depressants include drugs from the category of barbiturates and benzodiazepines. They are valuable medications for managing anxiety disorders and insomnia. Barbiturates, once used to induce and maintain sleep, have been replaced mainly by benzodiazepines due to barbiturate's toxicity, tolerance, and overdose risks. They interact with GABAA receptors, leading to sedation at low doses and potentially coma and death at higher doses. Phenobarbital, a long-acting barbiturate, possesses...
Insufficient Sleep and Sleep Deprivation01:13

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Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
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Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Insomnia01:27

Insomnia

Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
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Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...

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Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
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Sleeping problems among Chinese heroin-dependent individuals.

Yanhui Liao1, Jinsong Tang, Tieqiao Liu

  • 1Mental Health Institute, The Second Xiangya Hospital, Central South University, Hunan, China.

The American Journal of Drug and Alcohol Abuse
|March 29, 2011
PubMed
Summary

Most heroin-dependent individuals in China suffer from poor sleep quality, linked to depression, smoking, and long-term drug use. Addressing sleep issues is crucial for effective heroin addiction treatment and relapse prevention.

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A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats
10:35

A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats

Published on: November 11, 2013

Area of Science:

  • Addiction Medicine
  • Sleep Medicine
  • Public Health

Background:

  • Heroin abuse presents a significant public health challenge, associated with high morbidity and mortality.
  • Sleep disturbances are frequently reported by individuals seeking treatment for heroin dependence, potentially increasing relapse rates.
  • Limited research exists on the prevalence of sleep disorders among Chinese heroin-dependent populations.

Purpose of the Study:

  • To investigate the prevalence of sleep disorders in Chinese heroin-dependent individuals.
  • To identify factors associated with poor sleep quality in this population.

Main Methods:

  • A survey-based study involving 140 heroin-dependent subjects in China.
  • Utilized self-report questionnaires: Pittsburgh Sleep Quality Index (PSQI), Zung's Self-Rating Anxiety Scale (SAS), and Zung's Self-Rating Depression Scale (SDS).

Main Results:

  • A high prevalence of poor sleep quality (PSQI score ≥ 8) was observed in 96.30% of participants.
  • Depressive symptoms, excessive smoking and drinking, and a history of long-term drug use were significantly associated with poorer sleep quality.
  • No correlation was found between anxiety levels or drug quantity and sleep disorders.

Conclusions:

  • The majority of heroin-dependent patients in this cohort reported poor sleep quality.
  • Depression, substance use (smoking, drinking), and duration of drug dependence are key factors linked to sleep disturbances.
  • Integrating sleep quality assessment and management into comprehensive heroin addiction treatment programs is recommended to potentially reduce relapse rates.