Novel functions for the anaphase-promoting complex in neurobiology

Sidharth V Puram1, Azad Bonni

  • 1Department of Pathology, Harvard Medical School, Boston, MA 02115, United States.

Abstract

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Microtubules form through the end-to-end polymerization of tubulin heterodimers. Kinetochore microtubules originate from the spindle poles, and their plus-ends connect with the kinetochores on sister-chromatids. Ndc80 protein complexes, present on the kinetochore, form low-affinity links with the plus end of these kinetochore microtubules.
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