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AID and partners: for better and (not) for worse
Sébastien Storck1, Said Aoufouchi, Jean-Claude Weill
1Institut National de la Santé et de la Recherche Médicale Unité 783 Développement du système immunitaire, Université Paris Descartes, Faculté de Médecine, Site Necker-Enfants Malades, 156 rue de Vaugirard, 75730 Paris, Cedex 15, France.
Abstract:
Post-rearrangement diversification of the antibody repertoire relies on a DNA editing factor, the cytidine deaminase AID. How B lymphocytes avoid generalized mutagenesis while expressing high levels of AID remained a long-standing question. Genome-wide studies of AID targeting combined to the discovery of several co-factors controlling its recruitment and its local activity shed new light on this enigma.
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