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Updated: Jun 3, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
[Simplification to lopinavir/ritonavir monotherapy in HIV-infected children]
A Mur-Sierra1, N López-Segura, M A López-Vílchez
1Servicio de Pediatría, Hospital del Mar, Barcelona, España. AMur@parcdesalutmar.cat
Abstract:
Lopinavir/ritonavir monotherapy as a simplification strategy has the potential to minimize antiretroviral treatment toxicity without losing efficacy in selected cases, according to studies in adults, but little is known in paediatric patients. We report 5 children on this regimen for a median time of 112 weeks. One child with suboptimal adherence required intensification therapy to re-suppress viral load. Randomised controlled trials are needed to evaluate the efficacy of this strategy in children in order to make appropriate recommendations.
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