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A bacterial virulence determinant encoded by lysogenic coliphage lambda.

J J Barondess1, J Beckwith

  • 1Program in Cell and Developmental Biology, Harvard Medical School, Boston Massachusetts 02115.

Nature
|August 30, 1990
PubMed
Summary
This summary is machine-generated.

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Phage lambda’s accessory genome contains genes expressed during lysogeny, enhancing bacterial survival in animal serum. This suggests lysogeny plays a role in bacterial pathogenesis and survival in animal hosts.

Area of Science:

  • Microbiology
  • Bacteriology
  • Virology

Background:

  • Phage lambda is extensively studied, but its dispensable genome functions remain unclear.
  • The phage lambda genome retains non-essential genes despite evolutionary pressure for economy.

Purpose of the Study:

  • Investigate the function of phage lambda's accessory genome during lysogeny.
  • Identify novel genes within the accessory genome and their roles in bacterial host survival.

Main Methods:

  • Gene expression analysis during lysogeny.
  • Protein localization studies (bacterial outer membrane).
  • Homology searches with known virulence and resistance genes.

Main Results:

  • Two accessory genes, lom and bor, are expressed during lysogeny, encoding host-cell envelope proteins.

Related Experiment Videos

  • Lom localizes to the bacterial outer membrane and is homologous to enterobacterial virulence proteins.
  • Bor expression significantly enhances Escherichia coli survival in animal serum, homologous to the ColV2-K94 iss locus.

    • Conclusions:

    • Phage lambda prophage is more transcriptionally active during lysogeny than previously assumed.
    • Lysogeny may contribute to bacterial survival in animal hosts.
    • Accessory genes in phage lambda may play roles in bacterial pathogenesis and virulence.