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06:59

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Antineoplastic agents extravasation from peripheral intravenous line in children: a simple strategy for a safer

Daniella Cristina Chanes1, Mavilde da Luz Gonçalves Pedreira, Maria Gaby Rivero de Gutiérrez

  • 1Nurse at the Chemotherapy Outpatient Unit, IOP GRAACC UNIFESP, SAO Paulo, Brazil. dani_chanes@yahoo.com.br

European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society
|March 29, 2011
PubMed

Insights

Two algorithms were developed to guide nursing care for preventing and managing extravasation during pediatric chemotherapy. These validated tools ensure safe, evidence-based patient care for children receiving antineoplastic agents.

Area of Science:

  • Pediatric Oncology Nursing
  • Chemotherapy Administration
  • Patient Safety

Background:

  • Infusion of antineoplastic agents via peripheral lines can cause severe adverse events, notably extravasation.
  • Effective extravasation prevention and management are critical components of safe, evidence-based nursing care.
  • Pediatric oncology nursing requires specialized protocols for managing chemotherapy-related risks.

Purpose of the Study:

  • To determine the content validity of two newly developed algorithms for guiding nursing care in pediatric chemotherapy extravasation.
  • To assess the agreement between Brazilian and United States pediatric oncology nurses regarding the algorithms' validity.
  • To ensure algorithms are evidence-based and applicable in diverse clinical settings.

Main Methods:

  • A descriptive validation study employing the Delphi Technique was conducted.
  • The study involved developing a data collection instrument, applying it to specialist nurses, and analyzing data iteratively.
  • Content validity was determined through specialist consensus and algorithm review.

Main Results:

  • The data analysis confirmed high content validity for both algorithms, with specialist agreement ranging from 92.8% to 99.0%.
  • Consensus thresholds of 80% or higher were met at every stage of the algorithm evaluation.
  • The rigorous validation process demonstrated strong inter-rater reliability among international nursing experts.

Conclusions:

  • The developed algorithms are validated for practical application in nursing care.
  • These tools are effective in preventing and managing extravasation associated with antineoplastic agent administration.
  • The algorithms provide a standardized, evidence-based approach to enhance safety in pediatric chemotherapy.
Abstract

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