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Related Concept Videos

Viral Structure00:56

Viral Structure

Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Subviral Agents01:29

Subviral Agents

Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
Coronavirus01:29

Coronavirus

Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...
Inhibitors Of Virion Release01:25

Inhibitors Of Virion Release

Viral replication and dissemination rely on efficient mechanisms for host cell entry, genome replication, assembly, and release. Influenza viruses, such as types A and B, are negative-sense single-stranded RNA viruses with a segmented genome, that depend on two critical surface glycoproteins to carry out these processes: hemagglutinin (HA) and neuraminidase (NA). HA initiates infection by binding to sialic acid residues on the surface of host epithelial cells, facilitating receptor-mediated...

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Related Experiment Video

Updated: Jun 3, 2026

Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
09:12

Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods

Published on: May 11, 2018

Structure of hepatitis E viral particle.

Yoshio Mori1, Yoshiharu Matsuura

  • 1Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.

Virus Research
|March 29, 2011
PubMed
Summary

Hepatitis E virus (HEV) structural features were revealed through recent 3D structure studies. This provides insights into HEV assembly, antigenicity, and host cell interactions.

Area of Science:

  • Virology
  • Structural Biology
  • Hepatology

Background:

  • Hepatitis E is a significant cause of acute hepatitis globally, primarily transmitted through fecal-oral or zoonotic routes.
  • The Hepatitis E virus (HEV) is a non-enveloped virus with a positive-sense RNA genome.
  • Understanding HEV structure is crucial for developing antiviral strategies and diagnostics.

Purpose of the Study:

  • To review the recently elucidated three-dimensional structures of HEV-like particles and their spike domains.
  • To provide insights into the structural basis of HEV particle assembly.
  • To explore the implications of HEV structure for antigenicity, host cell attachment, and virion packaging.

Main Methods:

  • Analysis of published three-dimensional structural data of HEV-like particles.

More Related Videos

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Related Experiment Videos

Last Updated: Jun 3, 2026

Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
09:12

Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods

Published on: May 11, 2018

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

  • Review of structural features of the HEV capsid subunit and the complete viral particle.
  • Integration of structural findings with known biological mechanisms.

    • Main Results:

    • Detailed structural features of HEV-like particles and their surface-exposed spike domains have been determined.
    • The capsid subunit and overall viral particle architecture have been characterized.
    • Structural insights into potential mechanisms of viral assembly and host interaction have been gained.

    Conclusions:

    • The revealed HEV structures offer a foundation for understanding viral assembly and maturation.
    • Structural information can guide the development of novel therapeutics and vaccines.
    • Further research into HEV structural biology is essential for combating Hepatitis E infection.