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Use of capsule endoscopy in diagnosis and management of pediatric patients, based on meta-analysis

Stanley A Cohen1, Alan I Klevens

  • 1Children's Center for Digestive Healthcare of Atlanta, Children's Healthcare of Atlanta, Georgia, USA. scohen@ccdhc.org

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|March 29, 2011
PubMed

Insights

Capsule endoscopy (CE) in children is primarily used for inflammatory bowel disease evaluation, especially Crohn's disease. This analysis shows CE aids diagnosis and management, with low retention rates similar to adults.

Area of Science:

  • Pediatric Gastroenterology
  • Diagnostic Imaging

Background:

  • Capsule endoscopy (CE) is an advanced diagnostic tool for evaluating the gastrointestinal tract.
  • Understanding its utility in pediatric populations is crucial for optimizing patient care.

Purpose of the Study:

  • To systematically analyze indications and outcomes of CE in pediatric patients.
  • To evaluate the effectiveness of CE in influencing patient management through meta-analysis.

Main Methods:

  • A comprehensive literature search of Medline and PubMed databases was conducted for studies on CE in patients 18 years or younger (January 2001-May 2010).
  • Data from 15 eligible studies, encompassing 740 CE procedures in 723 pediatric patients, were meta-analyzed.
  • Exclusion criteria included duplicate reports and studies with fewer than 5 patients.

Main Results:

  • Inflammatory bowel disease (IBD) suspicion or evaluation was the most common indication for pediatric CE (54%), particularly Crohn's disease (CD).
  • High completion rates (86.2%) and low retention rates (2.6%) were observed, comparable to adult CE.
  • CE procedures yielded positive findings in 65.4% of cases, leading to new diagnoses in 69.4% and changes in therapy in 68.3% of instances.

Conclusions:

  • Pediatric CE indications differ from adults, with a strong focus on diagnosing and managing IBD, especially CD.
  • CE is effective in pediatric patient management, aiding diagnosis, monitoring disease, and guiding therapeutic decisions.
  • Capsule retention rates are infrequent and appear to be indication-dependent rather than age-related.
Abstract

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