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Related Concept Videos

RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
Pre-mRNA Processing: RNA Splicing01:32

Pre-mRNA Processing: RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...

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Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

Gene structure and splicing in schistosomes.

Sergio Verjovski-Almeida1, Ricardo DeMarco

  • 1Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, 05508-900 São Paulo, SP, Brazil. verjo@iq.usp.br

Journal of Proteomics
|March 29, 2011
PubMed
Summary

Schistosomes, successful parasites, use sophisticated genetic programs to evade host immunity. Their genes generate protein diversity via alternate splicing, aiding survival and host interaction.

Area of Science:

  • Parasitology
  • Molecular Biology
  • Genomics

Background:

  • Schistosomes are successful blood flukes with complex life cycles requiring adaptation to distinct hosts.
  • Parasite survival hinges on sophisticated genetic mechanisms to overcome host immune defenses.
  • Secreted proteins are crucial for host-parasite interactions at the interface.

Purpose of the Study:

  • To investigate the genetic basis of Schistosome adaptability and host immune evasion.
  • To analyze gene structure and splicing in Schistosomes, focusing on secreted proteins.
  • To explore the role of protein variability in parasite survival and host interaction.

Main Methods:

  • Analysis of large-scale Schistosome genome and transcriptome data.
  • Characterization of gene structures, particularly for secreted proteins.

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A Reporter Based Cellular Assay for Monitoring Splicing Efficiency
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A Reporter Based Cellular Assay for Monitoring Splicing Efficiency

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Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

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A Reporter Based Cellular Assay for Monitoring Splicing Efficiency
08:53

A Reporter Based Cellular Assay for Monitoring Splicing Efficiency

Published on: September 15, 2021

  • Identification of genes with unusual structures, such as Micro-Exon Genes (MEGs), polymorphic mucin genes (SmPoMucs), and venom allergen-like (SmVALs) proteins.

    • Main Results:

    • Schistosomes possess genes with unusual structures, including MEGs, SmPoMucs, and SmVALs.
    • These genes appear optimized for generating protein diversity through alternate splicing.
    • Multiple gene copies of these types suggest a strategy for enhanced protein variability.

    Conclusions:

    • Schistosomes employ sophisticated genetic systems, including alternate splicing of unique genes, to generate protein diversity.
    • This protein variability is a key factor in their ability to interact with and survive within host environments.
    • Further proteomic studies are needed to fully understand the functional implications of this variability in host-parasite dynamics.