Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 3, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

Imaging devices for use in small animals.

Wade Koba1, Kami Kim, Michael L Lipton

  • 1M. Donald Blaufox Laboratory for Molecular Imaging, Department of Nuclear Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Seminars in Nuclear Medicine
|March 29, 2011
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The second decade of DTI in TBI part 1: a systematic review of mild TBI.

Frontiers in neurology·2026
Same author

Soccer heading and white matter microstructural changes: a two-year longitudinal cohort study.

Brain imaging and behavior·2026
Same author

Excited-State Electron-Phonon Coupling in Pristine and Doped Iron Pyrite.

The journal of physical chemistry letters·2026
Same author

Uip4 governs nuclear shape by modulating the Saccharomyces cerevisiae lipidome.

Journal of cell science·2026
Same author

The second decade of DTI in TBI Part 2: a systematic review of moderate and severe TBI.

Frontiers in neurology·2026
Same author

Generational differences in clock drawing test performance.

Journal of the International Neuropsychological Society : JINS·2026
Same journal

Letter from the Editors.

Seminars in nuclear medicine·2026
Same journal

Expanding Horizons: The Role of Kaleidoscope and Relevant Images in Seminars in Nuclear Medicine.

Seminars in nuclear medicine·2026
Same journal

The diagnostic performance and clinical value of [18F]FDG PET/CT in pleural mesothelioma - A systematic review and meta-analysis.

Seminars in nuclear medicine·2026
Same journal

Feasibility of treating neuroendocrine prostate cancer with anti-SSTR radioligands: A systematic review of imaging and treatment studies.

Seminars in nuclear medicine·2026
Same journal

<sup>18</sup>F-FDG -PET/CT in cardiac sarcoidosis: Diagnosis, therapy monitoring, and future directions.

Seminars in nuclear medicine·2026
Same journal

Maximizing diagnostic yield: A systematic review and deep dive into PSMA PET scan protocol variations for prostate cancer.

Seminars in nuclear medicine·2026
See all related articles

Small animal imaging advances translational research and drug development by enabling longitudinal studies and theranostics. This approach reduces animal use and links diagnostic and therapeutic agent development for human application.

Area of Science:

  • Biomedical imaging
  • Translational research
  • Drug development

Background:

  • Small animal imaging devices are crucial for preclinical drug development, mandated by regulatory bodies like the Food and Drug Administration.
  • Instruments include positron emission tomography (PET), single-photon emission computed tomography (SPECT), computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound, often analogous to human-scale devices.
  • Optical imaging techniques, scaled from cellular studies, are also vital for whole-body animal imaging.

Purpose of the Study:

  • To highlight the role of small animal imaging in advancing translational research and drug development.
  • To explain how multi-modal and hybrid imaging enhance data acquisition and analysis.
  • To introduce the concept of theranostics in preclinical research.

More Related Videos

Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging
09:43

Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging

Published on: October 16, 2017

Dual Raster-Scanning Photoacoustic Small-Animal Imager for Vascular Visualization
07:14

Dual Raster-Scanning Photoacoustic Small-Animal Imager for Vascular Visualization

Published on: July 15, 2020

Related Experiment Videos

Last Updated: Jun 3, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging
09:43

Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging

Published on: October 16, 2017

Dual Raster-Scanning Photoacoustic Small-Animal Imager for Vascular Visualization
07:14

Dual Raster-Scanning Photoacoustic Small-Animal Imager for Vascular Visualization

Published on: July 15, 2020

Main Methods:

  • Utilizing various imaging modalities (PET, SPECT, CT, MRI, ultrasound, optical imaging) in small animals.
  • Employing software algorithms and hybrid instruments for multi-modal data integration.
  • Developing diagnostic and therapeutic agents on similar molecular platforms for theranostic applications.

Main Results:

  • Longitudinal imaging improves research by enabling paired statistics, reducing animal sacrifice.
  • Imaging facilitates the parallel development of diagnostic and therapeutic agents, creating theranostic pairs.
  • Emerging theranostic agents include nanoparticles, aptamers, peptides, and antibodies for various imaging and therapeutic purposes.

Conclusions:

  • Small animal imaging is indispensable for modern drug development, bridging basic research and clinical application.
  • The theranostic paradigm, exemplified by existing and novel agents, offers a powerful approach for simultaneous diagnosis and therapy.
  • Continued innovation in imaging devices and theranostic agents will accelerate the translation of treatments to human patients.