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Hyperhomocysteinemia after kidney transplantation
B Einollahi1, M Lessan-Pezeshki, E Kalantar
1Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Baqiyatallah Hospital, Tehran, Iran. einollahi@ijnu.ir
Transplantation Proceedings
|March 29, 2011
Summary
Hyperhomocysteinemia is common in kidney transplant recipients. However, high homocysteine levels did not correlate with kidney allograft function in this study.
Area of Science:
- Nephrology
- Clinical Chemistry
- Transplantation Medicine
Background:
- Hyperhomocysteinemia, defined as plasma homocysteine (Hcy) concentration ≥15 μmol/L, is a potential risk factor in kidney disease.
- Understanding its prevalence and impact on renal allograft function is crucial for patient management.
Purpose of the Study:
- To determine the prevalence of hyperhomocysteinemia in stable renal transplant recipients.
- To evaluate the correlation between plasma Hcy levels and allograft function.
Main Methods:
- A cohort of 159 stable renal transplant recipients was compared with 72 patients on hemodialysis.
- Plasma total Hcy concentrations were measured and analyzed.
Main Results:
- The prevalence of hyperhomocysteinemia was 49% in transplant recipients versus 74% in hemodialysis patients.
- Mean Hcy levels were significantly higher in the hemodialysis group (27.4 μmol/L) compared to the transplant group (16.6 μmol/L).
- Serum creatinine concentration was identified as a major determinant of elevated Hcy in transplant recipients, but no correlation was found between Hcy and graft function.
Conclusions:
- Moderate hyperhomocysteinemia is prevalent in renal transplant recipients.
- No significant correlation was observed between Hcy concentration and renal allograft function.
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