Related Experiment Video

Updated: Jun 3, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

[Effect on ocular blood flow of Combigan® versus placebo in patients with ocular hypertension]

B Puerto-Hernández1, G Rebolleda, J L García-Pérez

  • 1Servicio de Oftalmología, Unidad de Glaucoma, IRYCIS, Hospital Ramón y Cajal, Madrid, España. beapuertoh@hotmail.com

Archivos De La Sociedad Espanola De Oftalmologia
|March 29, 2011
PubMed

Insights

Combigan significantly lowered intraocular pressure (IOP) and improved ocular hemodynamics in ocular hypertension (OHT) patients. This study compared Combigan versus placebo, revealing a notable decrease in the central retinal artery resistive index.

Area of Science:

  • Ophthalmology
  • Ocular hemodynamics
  • Medical research

Background:

  • Ocular hypertension (OHT) is a risk factor for glaucoma.
  • Understanding the ocular hemodynamic effects of OHT treatments is crucial.
  • Combigan is a common treatment for elevated intraocular pressure.

Purpose of the Study:

  • To compare the ocular hemodynamic effects of Combigan versus placebo.
  • To assess changes in retrobulbar blood flow in patients with OHT.
  • To evaluate the impact of Combigan on intraocular pressure and vascular resistance.

Main Methods:

  • A 3-month, randomized, double-blind, placebo-controlled study.
  • Thirty patients with OHT were divided into two groups (15 each).
  • Ocular hemodynamics (ophthalmic artery and central retinal artery blood flow) and intraocular pressure were measured using color Doppler imaging ultrasound at baseline and 3 months.

Main Results:

  • Combigan significantly reduced intraocular pressure (IOP) (P = 0.001).
  • Placebo did not show a significant change in IOP.
  • Combigan treatment led to a statistically significant decrease in the central retinal artery (CRA) resistive index (P = 0.007).

Conclusions:

  • Combigan treatment for 3 months significantly decreased the CRA resistive index in OHT patients.
  • This hemodynamic improvement may be attributed to the IOP-lowering effect of Combigan.
  • The study highlights Combigan's potential benefits beyond IOP reduction.
Abstract

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...