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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
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Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...

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Updated: Jun 3, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Circadian clock and cardiovascular disease.

Norihiko Takeda1, Koji Maemura

  • 1Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. ntakeda-tky@umin.ac.jp

Journal of Cardiology
|March 29, 2011
PubMed
Summary

Cardiovascular health is linked to circadian rhythms. Disruptions in the body's internal biological clock, or peripheral clocks in heart and blood vessels, can harm cardiovascular function and lead to disease.

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Last Updated: Jun 3, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
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In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

Area of Science:

  • Cardiovascular Physiology and Chronobiology
  • Molecular Mechanisms of Circadian Rhythms
  • Pathophysiology of Cardiovascular Diseases

Background:

  • Cardiovascular organ function, including heart rate and blood pressure, exhibits daily variations linked to circadian rhythms.
  • Cardiovascular disorders like acute coronary syndrome and atrial arrhythmia show diurnal patterns in onset.
  • Biological clocks, both central (suprachiasmatic nucleus) and peripheral (in cardiovascular tissues), regulate these rhythms.

Purpose of the Study:

  • To explore the roles of peripheral biological clocks in cardiovascular organs.
  • To understand how circadian rhythm disruptions contribute to cardiovascular pathology.
  • To investigate the potential for chronotherapeutic approaches in cardiovascular disease treatment.

Main Methods:

  • Review of recent studies on biological clock functions and molecular mechanisms in cardiovascular systems.
  • Analysis of findings from genetically engineered mouse models investigating peripheral clock contributions to disease.
  • Examination of the impact of desynchronization between central and peripheral clocks on cardiovascular health.

Main Results:

  • Peripheral clocks in cardiovascular tissues (heart, vessels, cells) possess intrinsic biological rhythms.
  • Loss of synchronization between internal clocks and external cues can cause cardiovascular damage.
  • Phase discrepancies between central and peripheral clocks are implicated in disease progression.

Conclusions:

  • Understanding peripheral clock roles in cardiovascular organs offers insights into circadian rhythm's relevance in cardiac pathology.
  • Manipulating peripheral clock phases could lead to novel chronotherapeutic strategies for cardiovascular disorders.
  • Time-of-day based treatments may revolutionize cardiovascular disease prevention and management.