Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Arch of Aorta

The Arch of Aorta

The coronary arteries, originating from the ascending aorta, bifurcate from two sinuses located within the ascending aorta. Positioned just above the aortic semilunar valve, these sinuses house essential aortic baroreceptors and chemoreceptors, crucial for maintaining cardiac function. The left coronary artery and the right coronary artery branch off from the left posterior and anterior aortic sinuses, respectively.
Encircling the heart, the coronary arteries form a ring-like structure before...

Hemorrhagic Stroke l: Introduction

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

Hemorrhagic Stroke ll: Pathophysiology

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

Cranial Bones: Superior and Posterior View

Cranial Bones: Superior and Posterior View

The superior view of the cranium shows the frontal and paired parietal bones.
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...

Arteries of the Head and Neck

Arteries of the Head and Neck

The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...

Cerebral Edema ll: Pathophysiology

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Family history of stroke and cardiovascular diseases in early-onset cryptogenic ischaemic stroke.

European stroke journal·2026

Same author

<i>COL4A1</i> and <i>COL4A2</i> Gene Duplication or Triplication as a Genetic Cause of Cerebral Small Vessel Disease in Adults.

Stroke·2026

Same author

Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage.

Annals of clinical and translational neurology·2025

Same author

Super-Refractory Status Epilepticus Diagnosis, Management, and Prognostication: An International Survey Study.

Neurology. Clinical practice·2025

Same author

Impact of Conventional Stroke Risk Factors on Early- and Late-Onset Ischemic Stroke: A Mendelian Randomization Study.

Stroke·2025

Same author

Genetic Testing for Monogenic Stroke.

Stroke·2024

Search research articles

Related Experiment Video

Updated: Jun 3, 2026

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Published on: July 21, 2013

Occipital bone abnormality causing recurrent posterior circulation strokes.

Carolyn A Cronin¹, E Francois Aldrich, Steven J Kittner

¹Department of Neurology, University of Maryland School of Medicine, 110 South Paca Street, Baltimore, MD 21201, USA. ccronin@som.umaryland.edu

|March 29, 2011

Summary

This summary is machine-generated.

Recurrent posterior circulation strokes in a young man were caused by a bony occipital protuberance compressing the vertebral artery. Surgical removal of this anomaly resolved the issue, preventing further neurological events.

More Related Videos

Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice

Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice

Published on: December 29, 2016

Related Experiment Videos

Last Updated: Jun 3, 2026

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Published on: July 21, 2013

Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice

Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice

Published on: December 29, 2016

Area of Science:

Neurology
Vascular Surgery
Developmental Anatomy

Background:

Recurrent strokes pose a diagnostic challenge, particularly when standard evaluations are inconclusive.
Posterior circulation strokes can result from various etiologies, including arterial dissection and thromboembolism.

Observation:

A young male patient presented with a 6-year history of recurrent posterior circulation strokes.
Initial stroke workups, including advanced imaging, did not reveal the underlying cause.
Detailed review of catheter and CT angiograms identified an occipital bony protuberance impinging on the left vertebral artery.

Findings:

The bony protuberance was identified as a developmental anomaly causing mechanical compression of the vertebral artery.
This chronic impingement likely led to local vessel injury, thrombosis, and distal embolization, resulting in recurrent ischemic strokes.
Surgical resection of the bony anomaly was successfully performed.

Implications:

This case highlights the importance of meticulous imaging review for identifying rare structural causes of stroke.
Surgical correction of vertebral artery compression by developmental bony anomalies can be an effective treatment for recurrent posterior circulation strokes.
Early diagnosis and intervention can prevent further neurological damage and improve patient outcomes.