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Updated: Jun 3, 2026

Aplysia Ganglia Preparation for Electrophysiological and Molecular Analyses of Single Neurons
Published on: January 13, 2014
Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia
Rong-Yu Liu1, Shreyansh Shah, Leonard J Cleary
1Department of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, The University of Texas Medical School at Houston, Texas 77030, USA.
Abstract:
Long-term memory and plasticity, including long-term synaptic facilitation (LTF) of the Aplysia sensorimotor synapse, depend on the activation of transcription factors that regulate genes necessary for synaptic plasticity. In the present study we found that treatment with 5-HT and behavioral training produce biphasic changes in the expression of CREB2, a transcriptional repressor. An immediate increase in CREB2 protein was followed by a subsequent decrease. The effects of these treatments persist for at least 24 h and are observed in isolated sensory neurons. This study suggests that the dynamics of CREB2 expression could contribute to the consolidation of memory.
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