Related Experiment Video
Updated: Jun 3, 2026

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells
Published on: March 10, 2016
Remembering one's identity: the epigenetic basis of stem cell fate decisions
1Division of Dermatology, Department of Medicine, University of California, San Diego, California, USA. gsen@ucsd.edu
Abstract:
Stem cells serve a vital role in multicellular organisms by constantly replenishing tissue with their differentiated progeny during normal homeostasis or damage. How these cells maintain their identities throughout the life of an organism is an area of intense research. In this review, we explore recent emerging evidence that stem cell fate decisions are based on their epigenome and specific epigenetic factors.
Related Concept Videos
Maintenance of the ES Cell State
Lineage Commitment
Chromatin Modification in iPS Cells
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
Methods of Nuclear Reprogramming
Multipotency of Hematopoietic Stem Cells
Stem Cell Niche

