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Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing
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A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase

Trevor Hinkley1, João Martins, Colombe Chappey

  • 1ETH Zürich, Institute of Integrative Biology, Zürich, Switzerland.

Nature Genetics
|March 29, 2011
PubMed
Summary

Understanding human immunodeficiency virus type 1 (HIV-1) drug resistance evolution is complex. This study reveals that epistatic interactions, not just individual mutations, significantly shape HIV-1 fitness landscapes, impacting drug resistance.

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