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Updated: Jun 3, 2026

Methodology for Sputum Induction and Laboratory Processing
Published on: December 17, 2017
Comparative clinical and airway inflammatory features of asthmatics with or without polyps
Lara Bilodeau1, Marie-Eve Boulay, Philippe Prince
1Centre de Recherche de l'Institute Universitaire de Cardiologie et de Pneumologie de Québec , Québec, Canada.
Background:
Nasal polyposis (NP) is associated with a more severe and steroid-resistant asthma.
Objective:
To compare clinical and airway inflammatory features of asthmatics with or without NP.
Methods:
Two groups of asthmatic patients were studied: group 1; n=39, with NP; group 2; n=40, without NP. Asthma control was assessed according to the Asthma Control Scoring System (ACSS). Expiratory flows, induced sputum, and blood eosinophils were also measured.
Results:
ACSS score was lower (poorer control) in group 1 (meanA+-SEM = 73A+-3%) compared with group 2 (82A+-2%, p=0.01). FEV1 (mean of predicted value A+- SEM) was 81A+-3 for group 1 and 96A+-3 for group 2 (p=0.001), and the FEV1/FVC ratio was lower in group 1 (70A+-2%) compared with group 2 (76A+-1%, p=0.01). Blood and induced sputum eosinophils, as well as fibronectin and eosinophil cationic protein levels, were higher in group 1.
Conclusion:
Asthmatic subjects with NP have increased airway obstruction, increased inflammatory cells and reduced asthma control compared to those without NP. This may suggest a contribution of nasal polyps to the severity of asthma or a common susceptibility to develop upper and lower airways mucosal inflammation.
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