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Topical ketoconazole for infantile seborrhoeic dermatitis.
A Taieb1, V Legrain, C Palmier
1Service de Dermatologie Pédiatrique, Hôpital des Enfants, Bordeaux, France.
Dermatologica
|January 1, 1990
Summary
Ketoconazole 2% cream effectively treated seborrhoeic rash in infants, with minimal absorption and no accumulation. Most infants showed significant improvement within 10 days.
Area of Science:
- Dermatology
- Pediatrics
- Pharmacology
Background:
- Seborrhoeic dermatitis is a common inflammatory skin condition in infants.
- Topical antifungal agents are a primary treatment modality.
Purpose of the Study:
- To evaluate the efficacy and safety of ketoconazole 2% cream for infant seborrhoeic dermatitis.
- To assess percutaneous absorption and plasma accumulation of ketoconazole.
Main Methods:
- An open-label study involving 19 infants with bipolar seborrhoeic rash.
- Daily application of ketoconazole 2% cream for 10 days.
- Evaluation of clinical improvement, percutaneous absorption, and plasma ketoconazole levels.
Main Results:
- 78.9% of infants achieved near-complete clearance of rash by day 10.
- Minimal percutaneous absorption of ketoconazole was observed.
- No detectable plasma ketoconazole accumulation occurred over the treatment period.
Conclusions:
- Ketoconazole 2% cream is an effective and safe topical treatment for infant seborrhoeic dermatitis.
- Treatment failures were associated with psoriasiform eruptions and probable atopic dermatitis.
- Minimal systemic absorption supports its use in pediatric populations.