Related Experiment Video
Updated: Jun 3, 2026
03:23
Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Eosinophilic oesophagitis: epidemiology, pathogenesis and management
Matthew Remedios1, Dianne Jones, Paul Kerlin
1The Wesley Hospital, Brisbane, Queensland, Australia. mremedios@mac.com
Drugs
|March 30, 2011
Summary
Eosinophilic esophagitis (EE) is an allergic condition affecting the esophagus, diagnosed by eosinophil counts in biopsies. Treatment involves dietary changes or medications like corticosteroids.
Area of Science:
- Gastroenterology
- Allergy and Immunology
Background:
- Eosinophilic esophagitis (EE) is increasingly diagnosed in children and adults.
- It is an atopic condition linked to allergens, characterized by eosinophilic infiltration of the esophagus.
- Symptoms vary by age, including abdominal pain and vomiting in children, and dysphagia and chest pain in adults.
Purpose of the Study:
- To review the clinico-pathological features, diagnosis, and treatment of eosinophilic esophagitis.
- To discuss the overlap between EE and gastro-esophageal reflux disease (GERD).
Main Methods:
- Review of clinical presentations, diagnostic criteria (≥15 eosinophils/HPF), and endoscopic findings.
- Analysis of current and emerging treatment strategies, including dietary modifications and pharmacotherapy.
Main Results:
- EE presents with distinct endoscopic features like linear furrows and mucosal rings.
- Topical fluticasone propionate improves symptoms and reduces eosinophil infiltration.
- Montelukast shows variable effects, while mepolizumab demonstrates promising results.
Conclusions:
- EE requires a multi-faceted approach combining dietary changes and pharmacotherapy.
- Topical corticosteroids are effective but long-term efficacy and symptom recurrence are concerns.
- Proton pump inhibitors may be considered due to the overlap with GERD.
Related Concept Videos
01:21Barrett Esophagus-II: Clinical Manifestations and Management
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
01:29Gastroesophageal Reflux Disease II: Clinical Features and Management
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
01:26Esophageal Strictures-II: Clinical Features and Management
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
01:20Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:26Peptic Ulcer Disease IV: Management
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current medication...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current medication...
01:28Esophageal Varices-II: Clinical Features and Management
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...