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Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Pulmonary Embolism I: Introduction01:19

Pulmonary Embolism I: Introduction

A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...
Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...

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Related Experiment Video

Updated: Jun 3, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Thrombophilias in pregnancy.

E M Battinelli1, K A Bauer

  • 1Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. ebattinelli@partners.org

Hematology/Oncology Clinics of North America
|March 30, 2011
PubMed
Summary

Thrombophilias increase the risk of blood clots during pregnancy. This review explores their impact on various pregnancy outcomes, including potential adverse effects.

Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Reproductive Medicine

Background:

  • Thrombophilic conditions elevate the risk of venous thromboembolic events (VTE) in pregnant individuals.
  • Disorders are categorized as acquired (e.g., antiphospholipid syndrome) or inherited (e.g., factor V Leiden).
  • While linked to VTE, acquired thrombophilias may also raise arterial event risks.

Purpose of the Study:

  • To discuss the multifaceted effects of thrombophilias on pregnancy outcomes.
  • To review the association between thrombophilias and adverse pregnancy events.
  • To clarify the controversy surrounding thrombophilias and pregnancy complications.

Main Methods:

  • Literature review of studies on thrombophilia and pregnancy outcomes.
  • Synthesis of evidence regarding VTE and other pregnancy complications.

Related Experiment Videos

Last Updated: Jun 3, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

  • Discussion of acquired versus inherited thrombophilic disorders.

    • Main Results:

    • Thrombophilias are confirmed risk factors for venous thromboembolism during pregnancy.
    • The impact of thrombophilias on outcomes like pregnancy loss, preeclampsia, and stillbirth remains debated.
    • Acquired thrombophilias present additional risks for arterial events.

    Conclusions:

    • Thrombophilias significantly influence pregnancy, primarily through VTE risk.
    • Further research is needed to fully elucidate the link between thrombophilias and adverse pregnancy outcomes.
    • Understanding these risks is crucial for managing high-risk pregnancies.