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Updated: Jun 3, 2026

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome
Kathryn G Ewens1, Michelle R Jones, Wendy Ankener
1Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Abstract:
Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.
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