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[Cell-derived microparticules: key players at the crossroad between inflammation and thrombosis]

F Sabatier1, R Lacroix, A-S Leroyer

  • 1Inserm UMR-S 608, UFR de pharmacie, 27, boulevard Jean-Moulin, 13385 Marseille cedex 5, France. florence.sabatier@ap-hm.fr

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|March 30, 2011
PubMed

Insights

Cell-derived microparticles, shed by endothelial cells, act as biological conveyors influencing vascular homeostasis. This review explores their role in pathologies and transfusion medicine.

Area of Science:

  • Biomedical science
  • Cell biology
  • Vascular biology

Background:

  • Cell-derived microparticles are vesicular structures released by activated or apoptotic endothelial cells.
  • They contain cytosolic components and transmembrane proteins, acting as biological conveyors.
  • These microparticles play a crucial role in regulating vascular homeostasis.

Purpose of the Study:

  • To review the potential of microparticles as vectors of biological activities in various pathologies.
  • To examine the contribution of endothelial microparticles to coagulation, inflammation, and angiogenesis.
  • To discuss the impact of cell-derived microparticles in blood products for transfusion medicine.

Main Methods:

  • This review synthesizes existing literature on endothelial vesiculation.
  • It analyzes the role of microparticles in vascular disorders based on the endothelial vesiculation model.
  • The review also considers the implications of microparticles in transfusion medicine.

Main Results:

  • Endothelial microparticles contribute to coagulation, inflammation, and angiogenesis.
  • They are implicated in the pathogenesis of various vascular disorders.
  • Cell-derived microparticles in blood products have significant relevance to transfusion medicine.

Conclusions:

  • Cell-derived microparticles are key players in vascular homeostasis and disease.
  • Understanding their role is crucial for developing new therapeutic strategies.
  • Their impact on transfusion medicine warrants further investigation.

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